Diamond & Pearl is the name given to the first main expansion of the Diamond & Pearl Series of the Pokémon Trading Card Game. In Japan, it was released as Diamond Collection and Pearl Collection, collectively known as Space-Time Creation, the first expansion in the Pokémon Card Game DP Era. It is based on Pokémon Diamond and Pearl, featuring Generation IV Pokémon and the two game Legendary Pokémon Dialga and Palkia. The English expansion was released on May 23, 2007, while the Japanese expansion was released on November 30, 2006.

Diamond & Pearl introduced Pokémon LV.X, a type of Pokémon. Pokémon LV.X are "Level-Up Pokémon" and is able to use any attack, Poké-Power, or Poké-Body from its previous Level. Poison-type Pokémon changed from being represented by the Grass-type to the Psychic-type. Supporter and Stadium cards were separate class of cards, rather than the subclass of Trainer cards. Both Darkness Energy and Metal Energy received new basic Energy forms which were free from the 4-per-deck rule. Cards that allow players to search for a Darkness or Metal Energy card may seek out either version. Unown were counted as separate Pokémon, with the letter after the name.

Diamond & Pearl also introduced an updated card design, which included numerous changes. The Pokémon's level returned and appeared on the right of the Pokémon's name. The word "HP" was smaller and appeared before the amount. The Evolution box moved to below the Pokémon's name. The Pokémon's Pokédex number, species, height, and weight were displayed below the artwork window. The circles on the left of the card no longer appeared. The Pokédex entry made its return and was located below the Pokémon Power and attack box. The illustrator's name was moved above the retreat cost.

A new numbering system for Pokémon was deployed on the lower left of the card, labelled DPBP#. This Diamond & Pearl Battle Pokédex number system combined aspects of the National Pokédex and the habitat system featured in Pokémon FireRed and LeafGreen. Japanese cards reverted to having no card numbering system. Darkness-type and Metal-type Pokémon were listed before Colorless-type Pokémon. Evolutionary family were listed together. Attacks that required no Energy were introduced.

With the release of this expansion, numerous rule changes took place. Outside of Asia, Trainer, Supporter, and Stadium cards were considered separate types. The player going first could now draw a card at the beginning of their first turn, but couldn't play any of the aforementioned cards.

Each booster pack were increased from 9 cards to 10 cards; they include 5 Common, 3 Uncommon, 1 Reverse Holofoil, and 1 Rare or Rare Holo card. The Reverse Holofoil were no longer being Holofoil on the background of the artwork, instead it was Holofoil on the entire card excluding the artwork. Reverse Holofoil versions of the Rare Holo cards were also no longer being Holofoil on the artwork.