Black & White is the name given to the first main expansion of the Black & White Series of the Pokémon Trading Card Game. In Japan, it was released as the Black Collection and White Collection dual expansions that make up the first expansion block in the Pokémon Card Game BW Era. It is based on Pokémon Black and White, featuring Generation V Pokémon and the two game Legendary Pokémon Reshiram and Zekrom. The English expansion was released on April 25, 2011, while the Japanese expansions were released on December 17, 2010. The concept of starting from a new beginning was brought into the Trading Card Game, thus Black & White was entirely composed of Generation V Pokémon, with the sole exception of Pikachu, which is a secret card.

Black & White introduced Ability, replacing the long-standing Poké-Powers and Poké-Bodies. Abilities essentially merge the active and passive effects of Poké-Powers and Poké-Bodies into a single mechanic, akin to Pokémon Powers present during the original and Neo Series. It also introduced Full Art cards. Full Art cards featured the artwork and Holofoil covering the entire card.

Several rule changes also came into effect with the release of Black & White. Item (named Goods in Japan), Supporter, and Stadium cards were reverted to being subclass of Trainer cards. They could once again be played during each player's first turn. The original rule that stipulated Supporter cards were to be discarded at the end of a player's turn had been changed to be discarded immediately after use. In Japan, Trainer cards were now written as "Trainer's" and Supporter cards were now written as "サポート". Neither of these changes had an effect on gameplay.

The procedure in which Knock Outs were carried out had been slightly altered. Previously, after the player with the Knocked Out Pokémon discarded that Pokémon, they would replace that Pokémon with one from their Bench, and the player performing the Knock Out would proceed to take one Prize card. This had been changed to the player performing the Knock Out taking one Prize card, then the player with the Knocked Out Pokémon replacing that Pokémon with one from their Bench. This change essentially prevented the player performing the Knock Out from selecting a Prize card based on their opponent's new Active Pokémon.

Black & White also introduced an updated card design, which included numerous changes. The card border of English prints were changed to yellow, while Japanese prints were changed to gray. The Stage area received a new graphic and were moved to the extreme top left with the Evolution circle below and the "Evolves from" beside the Evolution circle. There were curvy strips between the Pokémon's name and the HP, which gained additional layers upon evolving. The Weakness and Resistance were moved to the bottom left with the Retreat (shortened from Retreat Cost) below. The Pokédex entry was present on all Pokémon and was moved to the bottom right, inside of a frame. The copyright information was located on the extreme bottom left and the illustrator's name, card number and set symbol on the right. The Cosmos Holofoil was changed to a horizontal-striped pattern, named Tinsel Holofoil. In the Japanese prints, Holofoil were on the card border and the background of the artwork.